چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Atherosclerotic plaques, as a hallmark of CAD, cause chronic narrowing of coronary arteries over time and could also result in acute myocardial infarction (AMI). The standard treatments for ameliorating AMI are reperfusion strategies, which paradoxically result in ischemic reperfusion (I/R) injury. Sphingosine 1 phosphate (S1P), as a potent lysophospholipid, plays an important role in various organs, including immune and cardiovascular systems. In addition, high‐density lipoprotein, as a negative predictor of atherosclerosis and CAD, is a major carrier of S1P in blood circulation. S1P mediates its effects through binding to specific G protein‐coupled receptors, and its signaling contributes to a variety of responses, including cardiac inflammation, dysfunction, and I/R injury protection. In this review, we will focus on the role of S1P in CAD and I/R injury as a potential therapeutic target. |
| نویسنده | نفر چندم مقاله |
|---|---|
| آیناز میهن فر | اول |
| حمیدرضا نجابتی | اول |
| امیر فتاحی | سوم |
| زینب لطیفی | چهارم |
| مسعود پزشکیان | پنجم |
| عباس افراسیابی راد | ششم |
| ناصر صفائی آغبلاغ | هفتم |
| احمد رضا جودتی | هشتم |
| محمد نوری | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| s1p.PDF | 1397/08/03 | 33000 | دانلود |
| s1p paper.pdf | 1397/08/03 | 936520 | دانلود |
