| خلاصه مقاله | Recently, the importance of microRNAs in the pathogenesis of
various diseases has been intensely studied. These molecules
control the expression of genes after transcription by inhibiting
gene expression or inducing its degradation. So, the identification
of miRNAs in neurological disorders, including ALS
and related diseases, can make new advances in new molecular
diagnostic markers. On the other hand, Progresses in bioinformatics
have helped better understanding the role of these regulatory
factors. Here, ALS and diseases with similar phenotypic
symptoms including Progressive muscular atrophy (PMA) and
dementia are examined. Based on DisGenet database, common
genes among ALS and these two similar diseases identified.
Then miRNAs databases like Mirtarbase, MirDB, and mirtargetlinkhuman
were used to recognize the miRNAs which regulate
these genes. As a result, a number of miRNAs including
hsa-miR-142, hsa-miR-204, hsa-miR-211 and hsa-miR-302e
have been reported which can play a significant role in these
three diseases. Therefore, in this study, some novel miRNAs
have been introduced bioinformatically, which can be used by
researchers for further experimental studies. |