چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | بابک امامعلی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 64231 |
| عنوان فارسی مقاله | A Bioinformatic approach to identify novel mirSNPs in Huntington's disease |
| عنوان لاتین مقاله | A Bioinformatic approach to identify novel mirSNPs in Huntington's disease |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | سومین کنگره بین المللی و پانزدهمین کنگره ملی ژنتیک ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1397 |
| سال انتشار/ارائه میلادی | 2018 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1397/02/23 الی 1397/02/25 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://geneticscongress.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of medical genetics, faculty of medicine, Tabriz university of medical sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهرا بهمن پور | اول |
| مهسا طهماسبی وند | دوم |
| سید رضا موسوی | سوم |
| بهاره خادمی | چهارم |
| بابک امامعلی زاده | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Single nucleotide polymorphism (miR-SNPs) in miRNAs coding genes or target sites are implicated in pathogenesis of various disease. Such miR-SNPs may have significant role, due to the alteration of miRNA function, and can be a diagnostic marker. However, the role of miR-SNPs has not well understood in the progression of Huntington’s disease (HD). Here, we implemented a bioinformatic approach to identify miR-SNPs involved in HD. In a comprehensive study, miRNAs and related genes were examined from Gene Expression Omnibus (GEO) database and previous studies. On the other hand, SNPs located in target site of miRNAs were obtained from PolymiRTS and miRdSNP databases. Supporting the results, miRNA: mRNA: SNPs were further evaluated for their involvement in HD. Therefore, by in silico analysis some miRSNP such as miR-200a:rs9055: REST, miR-146a:rs2910164: FDFT1, miR:141:rs2234975: SIRT1 were identified which may have functional roles in pathogenesis of HD. Results showed that candidate miR-SNPs may affect regulation of target genes by modifying miRNAs function. In this study, a number of novel miR-SNPs introduced which could be considered by researchers for experimentally and validation studies. |
| کلمات کلیدی | miR-SNPs, in silico, Huntington's disease |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Supplemetn.pdf | 1397/07/26 | 9140967 | دانلود |
| IMG_1370.jpg | 1397/07/26 | 178520 | دانلود |
