چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Endothelial dysfunction plays an important role in pathogenesis of systemic lupus erythematosus (SLE). Considering the importance of serum soluble vascular cell adhesion molecule-1 as the most abundant of the circulating adhesion molecules increased as a result of endothelial dysfunction and the role of endothelin-1 in pathophysiology of SLE, this study aimed to evaluate serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy subjects. Methods: In this cross-sectional study, 60 SLE patients according to the Systemic Lupus International Collaborating Clinics classification criteria for SLE and 40 age and sex-matched healthy controls were included. In patients, clinical examination was performed and SLE disease activity index was assessed. Serum endothelin-1 and soluble vascular cell adhesion molecule-1 levels were measured using ELISA kits. Results: The meanstandard deviation age of patients and controls was 31.917.66 and 33.2010.08 years, respectively. Compared to healthy controls, serum soluble vascular cell adhesion molecule-1 (1023.8352.96 vs. 866.06109.91) and endothelin-1 (77.8316.27 vs. 54.4512.01) was significantly higher in SLE patients (P¼0.003 and P<0.001, respectively). The most common organs involved in patients were skin, joint and kidney. There were no significant differences in serum soluble vascular cell adhesion molecule- 1 and endothelin-1 levels according to organ involvement, activity of disease and the conventional serum markers of disease activity (P>0.05). There was no significant correlation between disease activity, organ involvement and negative or positivity of autoantibodies as well as serum complement with endothelin-1 and vascular cell adhesion molecule-1 levels (P>0.05). Conclusions: Although our study revealed higher serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy controls, there were no significant correlations between their serum levels with organ involvement and disease activity. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهرزاد حاج علیلوی بناب | اول |
| پیمان طیاری | دوم |
| امیر قربانی حق جو | سوم |
| علیرضا خبازی اسکویی | چهارم |
| آیدا مالک مهدوی | پنجم |
| نادره رشتچی زاده | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 0961203318796285.pdf | 1397/07/25 | 108058 | دانلود |
