چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Although beta-amyloid (Ab) has been regarded as the principal toxic factor in the pathogenesis of Alzheimer’s disease (AD), it plays important physiological roles in phenomena such as neuron survival, synaptic plasticity, and memory formation. There are numerous plausible reasons to assume that all of the mentioned pathological and physiological functions of Ab may be partially mediated via alpha 7 nicotinic acetylcholine receptor (nAChR). Agonistic and antagonistic aspects of Ab on nAChRs may explain this paradox in peptide–receptor function. It seems that Ab shows antagonistic effects on a7 nAChR in a dose-dependent manner, and its pathologic function may partially correlate with antagonization of the receptor. If this hypothesis is supported, the related mechanisms of neurotoxicity, neuroprotection, memory formation, and AD pathogenesis might be identified. In addition, such knowledge helps make a more valid interpretation of neuron signaling and a better design of AD animal models. In addition, it may provide new insights into AD therapy development via reducing the amount of Ab and inhibiting peptide aggregation. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید صدیق اعتقاد | اول |
| مهناز طالبی | دوم |
| مهدی فرهودی | سوم |
| صمد اسلام جمال گلزاری | چهارم |
| بابک صابرمعروف | پنجم |
| جواد محمودی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S2251729414000020-main.pdf | 1397/07/14 | 506461 | دانلود |
