Systematic study of Nd3+ on the structural properties of ZnO nanocomposite for biomedical applications; In‐vitro biocompatibility, bioactivity, photoluminescence and antioxidant properties

Systematic study of Nd3+ on the structural properties of ZnO nanocomposite for biomedical applications; In‐vitro biocompatibility, bioactivity, photoluminescence and antioxidant properties


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دانشگاه علوم پزشکی تبریز
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نویسندگان: بهارک دیوبند

کلمات کلیدی: Neodymium Rare earth elements Cell viability test Nanostructures

نشریه: 21397 , 5 , 37 , 2018

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نویسنده ثبت کننده مقاله بهارک دیوبند
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز تحقیقات ریز فناوری دارویی
کد مقاله 64022
عنوان فارسی مقاله Systematic study of Nd3+ on the structural properties of ZnO nanocomposite for biomedical applications; In‐vitro biocompatibility, bioactivity, photoluminescence and antioxidant properties
عنوان لاتین مقاله Systematic study of Nd3+ on the structural properties of ZnO nanocomposite for biomedical applications; In‐vitro biocompatibility, bioactivity, photoluminescence and antioxidant properties
ناشر 4
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Owing to the inconformity in ionic radius between Nd3þ and Zn2þ, the successful incorporation of Nd3þ ion into the ZnO nanocrystals still remains a great challenge. In the present study various doping ratios containing 1 wt%, 5 wt%, 7 wt% and 10 wt% of Nd3þ doped ZnO nanoparticles (Nd/ZnO NPs) were synthesized in which a bio-layer caped the NPs. SEM/EDX analysis was performed on the ZnO and Nd/ZnO NPs. In addition, the as-synthesized NPs were characterized using X-ray diffraction (XRD), dynamic light scattering (DLS), differential reflectance spectroscopy (DRS) and photoluminescence (PL) spectroscopy. The average size of Nd (5 wt%)/ZnO NPs was in the range of 6.22 and 15e18 nm based on XRD and SEM techniques, respectively. The measured band gap values for pure ZnO and Nd/ZnO NCs with doping ratios of 1 wt%, 5 wt%, 7 wt% and 9 wt% were equal to 3.46, 3.26, 3.05, 3.25 and 3.29, respectively. After inhalation, nanoparticles first interact with lung surfactant system and accordingly their toxic effects will appear on lungs cells such as A549 cell line. The effect of Nd/ZnO NPs to interact by human A549 cell line was evaluated by means of cell viability test. According to cell viability test the concentrations of 0.3 and 0.5 mg/mL of Nd/ZnO NPs induce a low toxicity. The present study shows that these toxic effects of Nd/ ZnO NPs can be rectified by capping its surface via the addition of a bio-layer around particles in order to prevent them from interacting A549 cell line.

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بهارک دیوبندسوم

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