چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| یلدا جعفری متنق | اول |
| آزاده منتصری | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | osteoarthritis , scaffold ,growth factor, chondrocytes, tissue engineering |
| خلاصه مقاله | Introduction: Articular cartilage is a semi - solid type of connective tissue with a poor capacity of self- repair due to the lack of blood vessels and lymphatics. Osteoarthritis(OA) is the most common type of arthritis affected millions of people and known as the second debilitating disease. OA occurs due to an imbalance between synthesis and degradation of extra-cellular matrix (ECM) companents. In normal cartilage this balance is controlled by chondrocytes, but during OA, ability of these cells for maintaining the (ECM) remodeling decreased. At molecular level, increased production of pro-inflammatory cytokines such as Inter leukin1-β (IL-1β) and tumor necrosis factor-α (TNF-α) is responsible for this imbalance. Different techniques are applied for cartilage repair such as drug therapies, surgical techniques and tissue engineering. Among these, tissue engineering has received more attention due to its capacity for reconstruction of cartilage lesion. This technique is a clinically driven field which compose of different elements including cell, scaffold and chemical factors. Great number of studies confirmed that use of anabolic growth factors such as IGF-1, TGF-β, PDGF and BMPs can enhance the chondrocyte proliferation and synthesis of ECM by them. So, application this promoting factor can shed lights on these way. The purpose of the present article is to review recent research regarding to the OA, it’s pathogenesis and also the current therapeautic methods in this line and their consequenses. Conclusion: Articular cartilage is disposed deterioration because of it’s avascular characteristic, low rate of ECM turnover and scarce number of chondrocytes. During chondrogenesis different anabolic growth factors are involved in development of this tissue, Nowadays it has been proved that mature cartilage homeostasis is also controlled by this factors. In this review article we collected related data about cartilage tissue and it’s common disease, osteoarthritis. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.JPG | 1397/06/28 | 809143 | دانلود |
| IMG_E2517.JPG | 1397/06/28 | 1663719 | دانلود |
