چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract In this study, the ability of methotrexate (MTX)-loaded stimuliresponsive novel silica nanocomposites (MSNs) (with mean diameter of 60 nm) in the induction of apoptosis, and change in the Bax/Bcl-2 mRNA levels, were investigated. MTT assay and RT -PCR analysis were performed on MDA-MB-231 breast cancer cells, to evaluate their anti-proliferative, apoptotic and antiapoptotic effects. MTX-loaded MSNs caused marked decrease in the percentage of viable cells, with a significant down-regulation in the level of expression of the anti-apoptotic gene (Bcl-2), and up-regulation in the apoptotic gene (Bax). MTX-loaded MSNs increased the efficacy of the chemotherapeutic agents in the inhibition of cell proliferation and induction of apoptosis. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناصر صمدی | چهارم |
| ندا علیدادیانی | اول |
| رویا صالحی قره ورن | دوم |
| شهروز قادری | سوم |
| سودابه داوران | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 91064606.pdf | 1397/06/16 | 1321794 | دانلود |
