چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| MicroRNAs (miRNAs) have had a revolutionary impact on cancer research over the recent years. They emerge as important players in tumourigenesis, leading to a paradigm shift in oncology. Ovarian cancer is the leading cause of death among gynaecologic malignancies. Therefore, there is a strong need for prognostic and predictive markers for early diagnosis which helps optimize and personalize treatment. Asymptomatically, ovarian cancer is often diagnosed at advanced and incurable stages. Efficient target-ing and sustained release of miRNAs/anti-miRNAs using nanoparticles conjugated with antibodies and/ or peptides could reduce the required therapeutic dosage while minimizing systemic and cellular tox-icity. Given miRNAs importance in clinical oncology, here we focus on the development of miRNA nano-formulations to achieve enhanced cellular uptake, bioavailability and accumulation at the tumour site. Although many obstacles need to be overcome, miRNA therapy could be a powerful tool for ovarian cancer prevention and treatment. In this review, we discuss about the emerging roles of miRNAs in vari-ous aspects of ovarian cancer. |
| نویسنده | نفر چندم مقاله |
|---|---|
| لیلا کفشدوز پورپل سنگی | اول |
| حجت پورفتحی نعمت آباد | دوم |
| طیبه کفشدوزپور پلسنگی | چهارم |
| ابوالفضل اکبرزاده | سوم |
| رقیه شیرولیلو | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| akbarzadeh.jpg | 1398/06/11 | 78141 | دانلود |
| The role of microRNAs and nanoparticles in ovarian cancer a review.pdf | 1397/06/21 | 1045844 | دانلود |
