چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Redox-responsive nanogels can encapsulate appropriate amount of active ingredient, deliver drugs to the target cells by the enhanced permeability and retention (EPR) effect or specific targeted groups, and finally, rapidly release the loaded drug at the site of action when the redoxstimulus is applied. These programmed site-specific drug delivery features cause unique drug delivery control in the stimuli-responsive nanogels and lead to superior in vitro and/or in vivo anti-cancer efficacy. Because of the high difference between the concentration of oxidative species in normal and tumor tissues, which is very important for biomedical applications particularly cancer therapy, the redox-responsive nanogels have received much attention among various stimuli-responsive nanogels. Thus, in this review, we attempt to summarize recent efforts to prepare innovative redox-responsive nanogels and discuss recent advances in the interface between drug delivery and stimuli-responsive nanogels that are able to control drug biodistribution in response to specific stimuli, with a particular emphasis on their design, drug release performance, and therapeutic benefits. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مرجان قربانی | اول |
| حامد همیشه کار | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.jpg | 1397/05/29 | 565653 | دانلود |
| Redox responsive smart nanogels for intracellular targeting of therapeutic agents applications and recent advances.pdf | 1397/06/15 | 2341869 | دانلود |
