| Aim: Antibiotic susceptibility patterns help to select appropriate empirical
treatments of urinary tract infections (UTIs). This study aimed to
Mina Yekani1,2
Hossein Bannazadeh
investigate antibiotic resistance among Enterobacteriaceae isolated Baghi1,2,3
from UTIs in Azerbaijan, Iran.
Fatemeh Yeganeh
Sefidan2,3
Methods: This study was carried out during 2016 in hospitals located
in Tabriz, Urmia, and Khoy. Midstream urine specimens were cultured
and identified by the standard methods. Susceptibility testing was car- Robab Azargun2,3
ried out using the disk diffusion agar method for cefotaxime, ceftazidime,
Mohammad Yousef
Memar1,2
ceftriaxone, cefoxitin, imipenem, meropenem, ertapenem, cefepime,
ampicillin, cefazolin, cefuroxime, aztreonam, nitrofurantoin, and fosfomycin
and the agar dilution method for MIC determination of aminoglycosides,
quinolones, sulfamethoxazole, and trimethoprim.
Reza Ghotaslou3
Results: A total of 219 non-duplicated Enterobacteriaceae were isolated
from UTIs. According to the agar dilution assay, the following resistance 1 Immunology Research
rates were determined: trimethoprim/sulfamethoxazole (co-trimoxazole) Center, Tabriz University of
Medical Sciences, Tabriz,
Iran
69.8%, nalidixic acid 68.9%, ciprofloxacin 66.2%, levofloxacin 58.5%,
tobramycin 47.9%, kanamycin 39.3%, gentamicin 27.8%, and amikacin
5.5%. High levels of resistance were observed to trimethoprim (78.5%),
sulfamethoxazole (88.1%), ampicillin (86.3%), and cephazoline (79.4%).
2 Microbiology Department,
School of Medicine, Tabriz
University of Medical
Sciences, Tabriz, Iran
Conclusion: The most effective agents against Enterobacteriaceae were
fosfomycin, carbapenems, and amikacin. Quinolones, trimethoprim and
sulfamethoxazole are not appropriate for empirical therapy due to high 3 Infectious and Tropical
levels of resistance. Amikacin ismore effective among aminoglycosides Research Center, Tabriz
University of Medical
Sciences, Tabriz, Iran
and may be more effective, in complicated cases |