| خلاصه مقاله | There is no evidence that pharmacotherapy is effective in treating the core features of autism spectrum disorder including social and communication deficits, but medications have been shown to be useful in treating specific associated symptoms, such as hyperactivity, inattention, impulsivity, self-injury, aggression, temper tantrums, stereotyped movements, mood lability, anxiety, and obsessions and compulsions. So, by targeting these symptoms, pharmacotherapy can be useful for increasing the ability of autistic children to participate in educational and behavioral interventions.
To date, risperidone and aripiprazole, two atypical antipsychotics, have got FDA approval for the treatment of irritability, aggression, self-injurious behavior, and mood lability associated with autism spectrum disorder.
However, there are a variety of other agents that may be beneficial in reducing associated symptoms in autism. Among these, some have got more attention including SSRIs and other antidepressants (for compulsions), anxiety, and depression), stimulants and atomoxetine (for inattention and hyperactivity), naltrexone (for hyperactivity and self-injurious behavior), and clonidine (for hyperarousal).
Nevertheless, various other agents like mood stabilizers, β-Blockers, and oxytocin will be discussed during the presentation based on the levels of evidence for their efficacy. |