Determining the Risk of Intra-Comm unity Transmission of Tuberculosis in the Northwest of IranThrough 15 Loci Miru-Vntr Typing

Determining the Risk of Intra-Community Transmission of Tuberculosis in the Northwest of Iran Through 15 Loci Miru-Vntr Typing


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دانشگاه علوم پزشکی تبریز
دانشگاه علوم پزشکی تبریز

نویسندگان: سید رضا مودب , خلیل انصارین

کلمات کلیدی: tuberculosis, molecular epidemiology, 15 loci MIRU-VNTR, intra-community transmission, recent transmission

نشریه: 39483 , 27 , 7 , 2017

اطلاعات کلی مقاله
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نویسنده ثبت کننده مقاله سید رضا مودب
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه دانشکده پیراپزشکی
کد مقاله 63606
عنوان فارسی مقاله Determining the Risk of Intra-Comm unity Transmission of Tuberculosis in the Northwest of IranThrough 15 Loci Miru-Vntr Typing
عنوان لاتین مقاله Determining the Risk of Intra-Community Transmission of Tuberculosis in the Northwest of Iran Through 15 Loci Miru-Vntr Typing
ناشر 5
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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This study was carried out in order to investigating the effect of travelling on the transmission of tuberculosis from high- to lowburden TB countries. Mycobacteria samples isolated from patients of distinct and relatively co-related countries (Azerbaijan Republic and Tabriz [located in the northwest of Iran]) were analyzed through 15 loci MIRU-VNTR typing method. PCR was done using special primers for each of the loci; then the number of allele repeats for all loci were determined by the size of their fragments. Finally, the created numeric patterns for each isolate were analyzed and clustered, using MIRU-VNTRplus.org website. All 119 isolates dispersing at 106 distinct patterns were composed of 10 clusters with 23 members and 96 unique patterns. Nine and five loci had high and moderate discriminatory power, respectively, but only one of them was poor in clustering. The study showed that 89.08% of TB cases involved resulted from the reactivation pattern and 10.92% were related to ongoing transmission. Although Azerbaijan Republic is a higher-burden TB region than Tabriz and Azerbaijan people make frequent tours to Tabriz to receive low or free medical services, the findings showed no TB transmission from the regions at least during the year of the study.

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نویسنده نفر چندم مقاله
سید رضا مودبدوم
خلیل انصارینچهارم

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DETERMINING THE RISK OF INTRA-COMMUNITY TRANSMISSION.pdf1397/05/17519987دانلود