Riluzole can improve sensory and motor function in patients with acute spinal cord injury
Riluzole can improve sensory and motor function in patients with acute spinal cord injury
نویسندگان: علی مشکینی , فیروز صالحپور , جواد آقازاده , فرهاد میرزایی , سید احمد ناصری علوی
کلمات کلیدی: Pain, riluzole, sensory and motor function, spinal cord injury, trauma
نشریه: 46898 , 3 , 13 , 2018
| نویسنده ثبت کننده مقاله |
سید احمد ناصری علوی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
دانشکده پزشکی |
| کد مقاله |
63575 |
| عنوان فارسی مقاله |
Riluzole can improve sensory and motor function in patients with acute spinal cord injury |
| عنوان لاتین مقاله |
Riluzole can improve sensory and motor function in patients with acute spinal cord injury |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح دو – PubMed |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Background: Spinal cord injury (SCI) causes sensory, motor function and consists of a large proportion of patients that referred to trauma centers. Riluzole blocks the sodium channels and has possible supportive effects on the central nervous system. The aim of this study was to investigate the effect of riluzole on sensory and motor improvement and pain level in patients with acute SCI. Materials and Methods: In this clinical trial, sixty patients with acute SCI with A to C Frankel grade selected and randomly divided into two groups (each group included thirty patients). The two groups carefully matched in terms of age, sex, and Frankel class. Case group, in addition to conventional treatment, received riluzole and was evaluated after 6-week, 3-month, and 6-month periods in terms of sensory and motor status and compared with control group. Results: There were sixty patients divided into case and control groups. In the 6-week follow-up period and 3-month follow-up period, there was no significant difference between the two groups based on sensory and motor function (P = 0.053). In 6-month follow-up period, the difference was significant in case group (P = 0.001). Conclusion: The compressions between two groups demonstrated a significant difference in sensory and motor improvement and reduce pain level in patients with SCI. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| AsianJNeurosurg133656-3353688_091856.pdf | 1397/05/09 | 531817 | دانلود |