چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Tis study was conducted to evaluate the effect of estradiol benzoate (EB) and FSH on hormonal levels and stereology structure of testis in Ghezel lambs treated with Tamoxifen citrate (TC). Sixteen lambs (105-110 days old) were randomly allocated in two groups. Te control group (4 lambs) received distilled water (5 ml/day) by oral gavage for 30 days). Te treatment group (T 12 lambs) received frst Tamoxifen citrate (660 µg/kg by oral gavage for 30 days), and was then allocated into three groups: T-T that received TC (660 µg/kg by oral gavage), T-FSH that received FSH (3 mg/ kg, by IM), and T-EB that received EB (3 mg/kg, by IM) for 10 days. Te stereological evaluation of the lamb testes showed that the groups T-T, TCFSH and TC-EB showed extensive seminiferous tubular atrophy compared with control group. Te administration of TC with EB signifcantly (P<0.01) improved the volume of germinal epithelium compered to TT group but co-administration of FSH did not induce signifcant differences in this parameter, in comparison with T-T group (P<0.01). Te administration of TC increased the intertubular space, reduced testicular weight, the height of the germinal epithelium, spermatogenic and sertoli-leydig cells number (P<0.01). Tere was no signifcant variation on the volume of testis (length, height and width), seminiferous tubule, lumen, capsule and interstitium (P>0.01). Serum testosterone and FSH concentrations were signifcantly reduced (P<0.01) when lambs were treated with TC 20 mg/kg daily for 30 days. Tese fnding demonstrated that FSH and EB could be useful in improving testicular structure and function of testis following TC treatment. |
| نویسنده | نفر چندم مقاله |
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| بهزاد برادران | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RMV169_58_64.pdf | 1397/05/27 | 1839749 | دانلود |
