Type 1 diabetes: Through the lens of human genome and metagenome interplay
Type 1 diabetes: Through the lens of the human genome and metagenome interplay
نویسندگان: سپیده زنونی واحد , حکیمه مقدس ثانی , یلدا رهبرسعادت , ابوالفضل برزگری , یداله امیدی
کلمات کلیدی: Diabetes
Immune system
Microbiota
Probiotic
Mucosal immunity
نشریه: 4741 , - , 104 , 2018
| نویسنده ثبت کننده مقاله |
سپیده زنونی واحد |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات کلیه |
| کد مقاله |
63523 |
| عنوان فارسی مقاله |
Type 1 diabetes: Through the lens of human genome and metagenome interplay |
| عنوان لاتین مقاله |
Type 1 diabetes: Through the lens of the human genome and metagenome interplay |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Diabetes is a genetic- and epigenetic-related disease from which a large population worldwide suffers. Some
genetic factors along with various mutations related to the immune system for disease mechanism(s) have
contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification
of the initiation and/or progression of diseases to help patients. In the recent years, due to familiarity
with the role of gut microbiota in the health, it has been found that the changes of the microbial balance in the
industrialized societies can cause a battery of modern diseases, for which we have no specific definition of how
they emerge. This work aims to explore the relationship between the human gut microbiota and the immune
system along with their possible role in avoiding/emerging of type 1 diabetes (T1D) accompanied with the
relation between genome and metagenome and their imbalance in causing T1D. Moreover, it provides a novel
view on how to balance the intestinal microbiota by lifestyle to hinder the mechanisms leading to T1D. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| T1D.pdf | 1397/05/07 | 2017349 | دانلود |