چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Context: MicroRNAs (miRNAs) have recently been found to be important targets for cancer therapy in innate immunity. Such molecules are highly expressed in a wide variety of tumor cells and play an important role in immune responses, such as apoptosis. EvidenceAcquisition: WesearchedPubMed, Medline, ScopusandgooglescholardatabasesforthestudiespublishedfromJanuary, 1998 to October, 2017 with the following keywords: “TLRS”, “MicroRNA”, “cancer”, “HMGB1”, and “Melanoma” Results: MiRNAs are mainly classified into 2 different groups, tumor suppressors and oncogenes. MiRNAs are closely related to damage-associated molecular patterns and pathogen-associated molecular patterns through the innate immunity signaling pathways, such as Toll-like receptors (TLRs). This review was carried out to find the relation between melanoma miRNAs with innate immune signaling pathways, such as toll-like receptors and high-mobility group box 1. High-mobility groups (HMG) are danger signal molecules, which can involve damage-associated molecular patterns and manage microRNAs. Conclusions: The important point in this field is that miRNA targeted in the immune defense can regulate inflammatory cytokines and alter cancerous phenotypes. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیامک صندوقچیان | اول |
| بهزاد برادران | دوم |
| حمیده هریزچی قدیم | سوم |
| زهره بابالو | چهارم |
| لیلا سادات حاتم نژاد | پنجم |
| ارمغان قره آغاجی زارع | ششم |
| حمیده عظیمی علمداری | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ijcm-In_Press-In_Press-11935 (1).pdf | 1397/05/27 | 1759304 | دانلود |
