چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا میرزائی باویل | اول |
| شیرین ببری | دوم |
| فرزاد بهاری | سوم |
| میلاد محمدزاده | چهارم |
| نوید نظر پور اجیرلو | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Objective: Dihydrotestosterone(DHT)is an endogenous hormone that is derived from testosterone in enzymatic reaction mediated by 5-alpha reductase. The high density of androgen receptors and 5-alpha reductase enzyme have been found in hippocampus. According to recent studies androgens may have improving effect in spatial memory on the other hand kindling results in learning and memory impairment in rats. In this study we investigate the effect of DHT intrahippocampal injection on spatial memory in male kindled rats. Materials and Methods: Animals were randomized in seventeen groups of eight. In all groups except the control group, two cannulas in both directions in CA1 hippocampus, was built with the help of stereotaxic surgery. In kindle groups were placed a 3-pole electrode with a cannula in the right side. On the first day of kindling was determined threshold. The intensity of stimulation in the CA1 region were given 10 micro amps. If the discharge was recorded for at least 5 seconds, flow was enough. Otherwise, flow rate increased to obtain the stimulation threshold. The animals were stimulated every 24 hours to reach kindling. Morris Water Maze was used to assess spatial memory. In addition to comparing drug carriers (DMSO) with saline, sham and kindled, injection of three doses of DHT (20-10-5 μg), 30 minutes before and after stimulation or 30 minutes prior to the Morris Water Maze ( MWM) were studied.. Findings: Our findings showed that injection of DHT in doses of 10 and 20 microgram, before test, can improve acquisition and retrieval in kindled male rats(p<0.05).But injection hadn’t effect on learning , memory and seizure parameters, before and after stimulation . Conclusion: Our results showed that intrahippocampal DHT can improve acquisition and retrieval in kindled rats but it doesn't have any effect on seizure parameters. |
| کلمات کلیدی | Dihydrotestosterone , Seizure, Acquisition, Retrieval, Kindling, 5-alpha reductas |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| chabahar.pdf | 1397/04/24 | 56424 | دانلود |
| Invitation letter Dr Fariba Mirzaei Bavil.pdf | 1397/04/24 | 104539 | دانلود |
