Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation

Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation


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نویسندگان: مسعود دارابی امین , لعیا فرزدی , علی سلماسی , زینب لطیفی , امیر مهدی زاده حقیقی , مقصود شاکر , توحید قاسم نژاد , لیلا روشنگر , محمد نوری , امیر فتاحی

کلمات کلیدی: Embryo implantation Pre-implantation window Fatty acids Omega-3 Omega-6 Arachidonic acid

نشریه: 33484 , 4 , 108 , 2018

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نویسنده ثبت کننده مقاله امیر فتاحی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه سلامت باروری زنان
کد مقاله 63390
عنوان فارسی مقاله Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation
عنوان لاتین مقاله Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation
ناشر 10
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Since fatty acid composition of uterus phospholipids is likely to influence embryo implantation, this study was conducted to investigate the effects of dietary omega-3 and -6 fatty acids on implantation rate as well as uterine phospholipid fatty acids composition during mice pre-implantation period. Sixty female mice were randomly distributed into:1) control (standard pellet), 2) omega-3 (standard pellet þ 10% w/w of omega-3 fatty acids) and 3) omega-6 (standard pellet þ 10% w/w of omega-6 fatty acids). Uterine phospholipid fatty acid composition during the pre-implantation window (days 1e5 of pregnancy) was analyzed using gas-chromatography. The implantation rate on the fifth day of pregnancy was also determined. Our results showed that on days 1, 2 and 3 of pregnancy, the levels of arachidonic acid (ARA) as well as total omega-6 fatty acids were significantly higher and the levels of linolenic acid and total omega-3 fatty acids were statistically lower in the omega-6 group compared to the omega-3 group (p < 0.05). On the fourth day of pregnancy, only the ARA, total omega-6 fatty acids, and polyunsaturated fatty acids levels were significantly different between the two dietary supplemented groups (p < 0.05). There were positive correlations between the levels of omega-6 fatty acids, especially ARA, with the implantation rate. The present study showed that diets rich in omega-3 and -6 fatty acids could differently modify uterine phospholipid fatty acid composition and uterine levels of phospho

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نویسنده نفر چندم مقاله
مسعود دارابی امیندوم
لعیا فرزدیسوم
علی سلماسیچهارم
زینب لطیفیپنجم
امیر مهدی زاده حقیقیششم
مقصود شاکرهفتم
توحید قاسم نژادهشتم
لیلا روشنگرنهم
محمد نوریدهم
امیر فتاحیاول

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