Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation
Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation
نویسندگان: مسعود دارابی امین , لعیا فرزدی , علی سلماسی , زینب لطیفی , امیر مهدی زاده حقیقی , مقصود شاکر , توحید قاسم نژاد , لیلا روشنگر , محمد نوری , امیر فتاحی
کلمات کلیدی: Embryo implantation
Pre-implantation window
Fatty acids
Omega-3
Omega-6
Arachidonic acid
نشریه: 33484 , 4 , 108 , 2018
| نویسنده ثبت کننده مقاله |
امیر فتاحی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
سلامت باروری زنان |
| کد مقاله |
63390 |
| عنوان فارسی مقاله |
Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation |
| عنوان لاتین مقاله |
Effects of dietary omega-3 and -6 supplementations on phospholipid fatty acid composition in mice uterus during window of pre-implantation |
| ناشر |
10 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Since fatty acid composition of uterus phospholipids is likely to influence embryo implantation, this
study was conducted to investigate the effects of dietary omega-3 and -6 fatty acids on implantation rate
as well as uterine phospholipid fatty acids composition during mice pre-implantation period. Sixty female
mice were randomly distributed into:1) control (standard pellet), 2) omega-3 (standard
pellet þ 10% w/w of omega-3 fatty acids) and 3) omega-6 (standard pellet þ 10% w/w of omega-6 fatty
acids). Uterine phospholipid fatty acid composition during the pre-implantation window (days 1e5 of
pregnancy) was analyzed using gas-chromatography. The implantation rate on the fifth day of pregnancy
was also determined. Our results showed that on days 1, 2 and 3 of pregnancy, the levels of arachidonic
acid (ARA) as well as total omega-6 fatty acids were significantly higher and the levels of linolenic acid
and total omega-3 fatty acids were statistically lower in the omega-6 group compared to the omega-3
group (p < 0.05). On the fourth day of pregnancy, only the ARA, total omega-6 fatty acids, and polyunsaturated
fatty acids levels were significantly different between the two dietary supplemented
groups (p < 0.05). There were positive correlations between the levels of omega-6 fatty acids, especially
ARA, with the implantation rate. The present study showed that diets rich in omega-3 and -6 fatty acids
could differently modify uterine phospholipid fatty acid composition and uterine levels of phospho |
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اندازه فایل |
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| a96-29-dr nouri.pdf | 1397/06/20 | 402997 | دانلود |
| IMG-20171226-WA0000.jpg | 1397/06/30 | 236705 | دانلود |