چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Background and aims: There is persuasive evidence that oxidative stress and inflammation are features of the metabolic syndrome (MetS). We have investigated the relationship between serum pro-oxidant antioxidant balance (PAB), serum uric acid and high sensitive C-reactive protein (hs-CRP) in 7208 participants from the MASHAD study cohort, who were categorized as having MetS, or not, using IDF criteria. Methods: Serum fasting lipid, fasting blood glucose and uric acid concentrations were measured enzymatically using commercial kits on a BT- 3000 autoanalyzer (Biotechnical, Rome, Italy). Serum hs-CRP was measured by PEG-enhanced immunoturbidimetry method using an Alycon analyzer (ABBOTT, Chicago, IL, USA). A colorimetric method was used to determine serum PAB. Results: Serum PAB values were significantly higher in the individuals with MetS compared to those without MetS (p<0.001). Furthermore, there was a step-wise increase in mean serum PAB concentrations as the number of components of the MetS increased. The combination of features of MetS had different association with serum PAB and hs-CRP. Multiple linear regression analysis showed that BMI (B=2.04, p<0.001), physical activity level (B=18.728, p=0.001), serum uric acid (B=-1.545, p=0.003) and serum C-reactive protein (B=0.663, p<0.001) were associated with serum PAB in individuals with MetS. Multiple logistic regression showed that serum PAB (B=0.002, p<0.001, CI=1.001-1.003), serum C-reactive protein (B=0.007, p<0.015, CI=1.001-1.013) and serum uric acid (B= 0.207, P<0.001, B=1.186-1.277) were associated with MetS. Conclusions: In a large population sample derived from the MASHAD cohort study, serum PAB was strongly associated with serum uric acid and serum hs-CRP. Moreover, serum PAB as well as serum uric acid and serum hs-CRP were independently associated with MetS. Interactions between individual features of MetS are also associated with serum hs-CRP and PAB. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهسا احمدنژاد | اول |
| سید رفیع عارف حسینی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1002@biof.1424.pdf | 1397/04/10 | 655334 | دانلود |
