چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction Long-chain polyunsaturated fatty acids, the most abundant fatty acids in the brain, are essential for the growth and development of the brain and the retina. Objective To evaluate the efect of fsh oil supplementation on the development (primary outcome) and growth of 4- and 6-month-old infants. Methods In this triple-blind randomized controlled trial, 150 pregnant women aged 18–35 years, who were referred to healthcare centres of Tabriz-Iran, were randomly allocated into two groups. One group of women consumed fsh oil supplementation (containing 120 mg docosahexaenoic acid and 180 mg eicosapentaenoic acid) daily, while the other consumed a placebo from the 20th week of pregnancy till 30 days after childbirth in a parallel design by a computer-generated block randomization scheme. The neurodevelopment of infants was the primary outcome; it was assessed using the ages and stages questionnaire (ASQ) at 4- and a-6 months of age. The growth of these infants was measured using weight, length and head circumference. The participants, the caregivers, and those assessing the outcomes were blind to the group assignment. Results Only one woman in the placebo group discontinued the intervention because of persistent severe nausea. All 75 neonates aged 4- and a-6 months in the fsh oil supplementation group, along with 73 and 71 neonates aged 4 and 6 months, respectively in the placebo group, were followed and analysed. Although the mean scores of neurodevelopment at the end of 4 and 6 months were higher in the supplemented group than in the placebo group in each ASQ domain, a statistically signifcant diference was observed only in the communication domain at the 4th month (adjusted mean diference 2.63; 95% confdence interval 0.36–4.89). There was no signifcant diference in weight, length, or head circumference between the two groups of infants aged 4 and 6 months (P ≥ 0.05). Conclusion Based on the results, perinatal fsh oil supplementation is benefcial for the communication domain of neurodevelopment of 4-month-old infants. The study results relating to the supplementation efect on other domains are inconclusive. There ought to be further studies with up-to-date lipidomic analysis to fnd biochemical correlate compared to an intervention and developmental fnding. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا استاد رحیمی | اول |
| هانیه صالحی پورمهر | دوم |
| سکینه محمد علیزاده چرندابی | سوم |
| سیف اله حیدرآبادی | چهارم |
| عزیزه فرشباف خلیلی | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1007_s00394-017-1512-1.EJN.pdf | 1397/04/08 | 1071470 | دانلود |
