چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The study introduces different organosilicon derivatives incorporating sulfanyltetrazole ring for biological applications. Initially, the sulfanyltetrazole derivatives and halo-analogues (Br, I) were synthesized. Later, selective reaction of tris(trimethylsilyl)methyllithium (TsiLi) in the presence (−46 and 0 °C) and absence (room temperature) of CS2 with halo-sulfanyltetrazole derivatives yielded new multifunctional sulfanyltetrazole regioisomers with SH, C = S, ethynylthio and SiMe3 groups, respectively. All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR spectra and elemental analysis data. The compounds were screened for their antibacterial activities against clinically important gram-positive and gram-negative bacteria using the spectrophotometric microdilution method. The preliminary screening indicated that the organosilicon derivatives incorporating SH and C = S (mercapto-silyl-thiones) and silyl-thioalkynes have antibacterial activities, whereas no antibacterial activity was observed on compounds containing ( Me3Si)3C groups. Of the synthesized compounds, compound 5d showed the best activity against all the tested organisms (3.91–31.25 μg/mL). |
| نویسنده | نفر چندم مقاله |
|---|---|
| خسرو ادیب کیا | سوم |
| فرزانه لطفی پور بناب | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Bulky organosilicon compounds based on sulfanyltetrazoles.pdf | 1397/04/04 | 700436 | دانلود |
