چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objective: There is a promising perspective regarding the potential effect of resveratrol in preventing and treating metabolic disturbances similar to that of calorie restriction. The aim of this study was to evaluate the effects of calorie-restricted (CR) diet on metabolic parameters and then to investigate whether resveratrol supplementation has beneficial effects similarly to CR diet in patients with nonalcoholic fatty liver disease (NAFLD). Methods: This randomized, controlled clinical trial was conducted on 90 patients with NAFLD (males and females) aged 20 to 60 years and body mass index (BMI) ranged 25-35 kg/m2. Subjects assigned to one of three intervention groups as follows: CR diet group (n=30) received a prescribed low-calorie diet, resveratrol group (n=30) received 600 mg pure trans-resveratrol (2×300 mg) daily and placebo group (n=30) received placebo capsules (2×300 mg) daily for 12 weeks. Fasting blood samples, anthropometric measurements, dietary intake and physical activity data were collected for all subjects at baseline and at the end of the trial. Results: CR diet significantly reduced weight (by 4.5%), BMI, waist circumference, waist to hip ratio and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lipid profile of subjects compared to resveratrol and placebo groups (All p<0.05). Significant reductions in weight (by 1.1%) and BMI were found in the resveratrol group compared to the placebo (P<0.05). ALT, AST and lipid profile did not change significantly in the resveratrol group (All P>0.05). No significant changes were seen in hepatic steatosis grade, serum glycemic parameters, HDL-C and sirtuin-1 levels in any group (All P>0.05). Conclusion: CR diet with moderate weight loss has favorable effects on NAFLD and resveratrol supplementation induced weight loss but failed to mimic other aspects of CR. Future studies are warranted to evaluate the long-term and dose-dependent effects of resveratrol on metabolic diseases. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیه اصغری | اول |
| محمد اصغری جعفرآبادی | دوم |
| مصطفی قوامی | سوم |
| محمد حسین صومی | چهارم |
| مریم رف رف | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| JACN.png | 1397/05/09 | 74635 | دانلود |
| Comparison of Calorie Restricted Diet and Resveratrol Supplementation on Anthropometric Indices Metabolic Parameters and Serum Sirtuin 1 Levels in.pdf | 1397/06/26 | 787317 | دانلود |
