| Background: Patellofemoral pain syndrome (PFPS) is characterized by anterior knee pain
due to arthralgia in the joint between the patella and femur. Many factors including improper
biomechanics and skeletal disorders are associated with PFPS. The role of vitamin D
deficiency in the pathogenesis of patellar chondromalacia has been known for several years.
Objectives: The aims of present study were to determine the prevalence of vitamin D
deficiency in young people with PFPS and compare it with prevalence in a healthy matched
control group and to determine correlation between occurrence of biomechanical
abnormalities and serum levels of 25(OH)D in patients with PFPS. Methods: In this casecontrol
study, 40 patients aged 15–40 years with a diagnosis of PFPS presenting to
rehabilitation clinic of a university hospital in Tabriz, Iran were selected as the case group
and 40 normal subjects of the same age range were selected as the controls. Serum
25(OH)D levels were assessed and a postural examination was performed in both groups,
while severity of knee pain,plain knee radiographs, and serum levels of calcium and
phosphorous were assessed only in PFPS patients. Results: Among the 80 participants,
vitamin D deficiency (cutoff level of 25(OH) D ≤20 ng/mL) was observed in 55 participants
(68.75%) including 35 (87.5%) patients and 20 (50%) controls, with statistically significant
difference (P<0.001). Women had a higher prevalence of vitamin D deficiency than men, but
the difference was not statistically significant (71.21% vs. 57.14%, P = 0.348). The serum
levels of vitamin D and pain severity were significantly and inversely related in the case
group (P=0.005). Clinical and imaging findings showed that 18 (45%) of the patients and two
(5%) of the controls had abnormalities such as genu varus, genu valgus, or patellar tracking,
indicating a high coexistence of biomechanical deficits in PFPS (P<0.001). Conclusion:
Severe and moderate vitamin D deficiencies were more prevalent in young adults with PFPS
than in normal adults. Knee pain severity and joint deformities were correlated with low levels
of vitamin D in the case group. Therefore, attention to diet, vitamin D supplementation and biomechanical correction are the mainstay of treatment. |