| Abstract: Background: Conventional dressings are cost-effective and highly absorbent, but not effectual
enough to promote hemostasis, adherence and in holding a moist wound bed. Thanks to the developments
in the field of nanotechnology and bioengineering, one of the promising current trends is to
move progress of innovative wound dressings, merging the application of traditional healing agents
and modern products/practices, such as hydrocolloids, hydrogels, films and nanofibers.
Objective: This review surveys on potentials of electrospun nanofibrous mats for wound dressing applications.
Furthermore, loading of bioactive molecules and therapeutic agents into the nanofibrous
mats especially natural compounds with the aim of fabrication novel bioactive electrospun nanofibrous
mats for skin substitutes and wound dressings are discussed.
Methods: Systematic literature search was conducted to review all recent progress toward the potential of
natural substances incorporated with electrospun nanofibrous scaffolds for wound dressing applications.
Results: The electrospun nanofibers webs can provide the essential parameters require for wound
dressing to heal wounds including absorptivity, oxygen permeability, and non-adherence to the healing
tissue, barrier to bacteria, bioactivity and occlusivity. The modern wound dressings materials made of
electrospun nanofibers contain various traditional healing agents such as plant derived compounds could
be beneficial to the healing of wounds. Natural substances have been used in skin wound care for many
years because of their therapeutic properties, including antimicrobial, antioxidant, anti-inflammatory and
mitogenic activities.
Conclusion: A screening of natural substances with plant or animal sources having high wound healer
activities and cooperating with electrospun nanofiber are an important step toward producing innovative
bioactive wound dressings |