چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N-methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1-methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation. The vasoprotective, anti-inflammatory and anti-thrombotic roles of MNAM have been well documented; however, the exact underlying mechanisms remain to be clarified. Due to potential role of MNAM in the formation of lipid droplets (LDs), it might exert its function in coordination with lipids, and their targets. In this study, we summarized the roles ofMNAMin cardiovascular system and highlighted its possible mode of actions. |
| نویسنده | نفر چندم مقاله |
|---|---|
| حمیدرضا نجابتی | اول |
| آیناز میهن فر | دوم |
| مسعود پزشکیان | سوم |
| امیر فتاحی | چهارم |
| زینب لطیفی | پنجم |
| ناصر صفائی آغبلاغ | ششم |
| محمد ولیلو | هفتم |
| احمد رضا جودتی | هشتم |
| محمد نوری | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| corresponding author consent.pdf | 1397/07/01 | 27925 | دانلود |
| mnam.pdf | 1397/02/27 | 684318 | دانلود |
