چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Cardiovascular disease is the most common illness in the developed and developing countries. Atherosclerosis is a cardiovascular inflammatory disease, which causes tissue destruction and fibrosis in the long run. On the other hand, atherosclerosis is a very common disease and is a multifactorial process. A potential role of some infectious agents has been suggested in the pathogenesis of atherosclerosis. This study aimed to determine the presence of Porphyromonas gingivalis, Chlamydia pneumonia, Helicobacter pylori, Mycoplasma pneumonia and Enterobacter hormaechei DNA in coronary artery atherosclerotic plaques by PCR analysis and the study of association between the presence of bacterial DNA and atherosclerosis, clinical, and demographic features of patients. Twenty-eight patients with atherosclerotic diseases who had undergone coronary artery bypass grafting surgery were included. Cinna Pure DNA Kit was used for extraction of total bacterial genomes. The presence of bacterial DNA in endarterectomy specimens were detected by the PCR using 16S rRNA and conserved specific primers. The significant statistic association between presence of different bacterial DNA and clinical and laboratory features of included patients were evaluated by χ2 and Fisher’s exact tests. C. pneumoniae and H. pylori DNA was detected in 4 out of 28 (14.3%) and 1 of 28 (3.6%) atherosclerotic plaques, respectively. DNA of Mycoplasma pneumonia, Enterobacter hormaechei and Porphyromonas gingivalis were not detected. There was no considerable difference between the presence of bacterial DNA and clinical and demographic features of patients. The higher rate of Chlamydia pneumoniae and Helicobacter pylori DNA in atherosclerotic damages suggest that these pathogens may play an important role in the pathogenesis of atherosclerosis progression. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید شیرگیر | اول |
| حسین بنازاده باغی | دوم |
| محمد یوسف معمار | سوم |
| ناصر صفائی آغبلاغ | چهارم |
| رضایت پرویزی | پنجم |
| ناصر علی زاده | ششم |
| رضا قوطاسلو | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 636-1478-1-PB.pdf | 1397/02/15 | 380146 | دانلود |
