| A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is
predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels,
making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of
cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the
various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy. |