چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | فرهاد بانی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 62492 |
| عنوان فارسی مقاله | Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy |
| عنوان لاتین مقاله | Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra05917a#!divAbstract |
| The aim of this study is to develop a nano graphene–polyglycerol–curcumin hybrid capable of simultaneous co-delivery of chemotherapeutic drug and cytotoxic heat to cancer cells by near infrared (NIR) laser irradiation. Based on a fluorescence quenching study, the nano graphene sheet was functionalized by a polyglycerol polymer via p–p interaction between the p conjugated system of graphene and the aromatic focal point of polyglycerol through static mechanism. The binding constant and standard Gibbs free energy change of the binding process, obtained from isothermal titration calorimetry (ITC), were 1.8 106 M1 and 35.7 kJ mol1, respectively. This hybrid showed excellent heat generation efficiency (DT z 60 C in 5 min, 1 W cm1 NIR laser) and high loading capacity of curcumin (61%). The resulting drug delivery system displayed a good stability with low drug release in PBS. However, NIR laser irradiation could trigger release of curcumin from the surface of the functionalized graphene sheet in PBS (up to 5-fold greater release) due to the local generated heat. Also the laser induced intracellular release of curcumin was confirmed by flow cytometry analysis. So the combination of chemo/photothermal therapy using this advanced drug delivery system demonstrated a synergistic effect for killing of MCF-7 breast cancer cells by MTT and apoptosis assays. |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرهاد بانی | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RSC Adv.Bani.pdf | 1396/12/19 | 3069075 | دانلود |
