Insecticide-impregnated dog collars reduce human visceral leishmaniasis under operational conditions in NW Iran: a community-wide cluster randomised trial

Insecticide-impregnated dog collars reduce human visceral leishmaniasis under operational conditions in NW Iran: a community-wide cluster randomised trial


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دانشگاه علوم پزشکی تبریز
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نویسندگان: احد بازمانی , عبدالصمد مظلومی گاوگانی

کلمات کلیدی: Insecticide–impregnated dog collars, visceral leishmaniasis , community–wide cluster randomised trial

نشریه: 34015 , s1 , 22 , 2017

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نویسنده ثبت کننده مقاله احد بازمانی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه بیماری های عفونی و گرمسیری
کد مقاله 62475
عنوان فارسی مقاله Insecticide-impregnated dog collars reduce human visceral leishmaniasis under operational conditions in NW Iran: a community-wide cluster randomised trial
عنوان لاتین مقاله Insecticide-impregnated dog collars reduce human visceral leishmaniasis under operational conditions in NW Iran: a community-wide cluster randomised trial
ناشر 5
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Proceeding
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
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Aims Reducing the burden of infantile visceral leishmaniasis (VL) due to Leishmania infantum requires interrupting sand fly vector–canine transmission. The efficacy of community-wide coverage with insecticide–impregnated dog collars has not been evaluated. Methods A pair matched–cluster randomised controlled trial involving 40 collared and 40 uncollared control villages (161 [95% C.L.s: 136, 187] children per cluster), was designed to detect a 55% reduction in 48 month confirmed VL case incidence. The intervention study was designed by the authors, but implemented by the Leishmaniasis Control Program in NW Iran. Results The collars provided 50% (95% C.I. 178%–700%) protection against VL case incidence (095/1000/yr compared to 175/1000/yr). Absolute median reductions of 11 fewer childhood cases (IQR 7.7–14.8; range: 08–54.1) per 1000 were observed across 76% (22/29) of collared villages compared to pair–matched control villages. In 11 paired villages, no further cases were recorded post–intervention. Seven collared villages experienced median increases of eight new cases (IQR 2.5–9.1; range: 091–12.9) per 1000 children. Conclusions Community–wide collar deployment can provide a significant level of protection against clinical VL, achieved in this study by the local VL Control Program. The collar protection did not completely interrupt transmission, but this was not attributed to intervention coverage,

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نویسنده نفر چندم مقاله
احد بازمانیسوم
عبدالصمد مظلومی گاوگانیدوم

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2018-Tropical_Medicine_&_International_Health.pdf1396/12/14145143دانلود