چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | بهرام پورقاسم گرگری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات علوم تغذیه |
| کد مقاله | 62431 |
| عنوان فارسی مقاله | نقش بلقوه پرو / پره بیوتیک بر پروفایل لیپیدی سرم، مقاومت انسولینی در کبد چرب غیر الکلی: کار آزمایی بالینی دو سو کور |
| عنوان لاتین مقاله | The Potential Role of Probiotics or/and Prebiotic on Serum Lipid Profile and Insulin Resistance in Non- Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=DaisyOneClickSearch&qid=4&SID=E1xL8NNyVIqV5ZFUimC&page=1&d |
| Abstract Objective: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease linked to insulin resistance and fatty acid synthesis. Insulin resistance plays an important role in the pathogenesis of NAFLD causing multiple lipid metabolism disorders. Supplementing probiotics and prebiotics is a complementary therapy in obesity-related disorders, including dyslipidemia and insulin resistance. The objective of this study was to evaluate the effect of probiotic and prebiotic supplementation on serum lipid profile and insulin resistance in patients with NAFLD. Materials and Methods: In this study, 84 subjects were divided into 4 groups. The first group received probiotic capsules (B.L and L.A: 2*107 CFU/d) and placebo of prebiotic (maltodextrin powder), the second group received prebiotic as sachet (inulin HP: 10 g/d) and placebo of probiotic (fat- and lactose-free milk capsules), the third group received probiotic and prebiotic, and the fourth group received a placebo of probiotic and prebiotic, for 3 months. Anthropometric characteristics, insulin resistance biomarkers and lipid profile were measured for all patients before and after the intervention. The primary outcome of the study was the Homeostasis model of assessment insulin resistance (HOMA-IR) level. The remaining variables (i.e., glucose, insulin, TC, TG, HDL, LDL, weight and BMI changes) were considered represent secondary outcomes. Results: Results showed that probiotic consumption was able to decrease BMI and weight in all the intervention groups in comparison to the placebo group. The serum levels of HDL and LDL differed significantly in the probiotic and pro- and prebiotic groups in comparison to the placebo group. In addition, there were no statistically significant reduction in TC, glucose, insulin levels and HOMA-IR in the intervention groups in comparison to the placebo group. Based on the analysis of covariance (ANCOVA) test, there were significant differences in HDL (P=0.005) and LDL (P=0.028) serum levels between the groups at the end of the study. Conclusion: Probiotic and prebiotic supplementation may be effective in improving serum lipid profile and insulin resistance markers in patients diagnosed with NAFLD. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مصطفی قوامی | دوم |
| منوچهر خوشباطن | سوم |
| عبدالرسول صفائیان | چهارم |
| ابوالفضل برزگری | پنجم |
| بهرام پورقاسم گرگری | ششم |
| لیلا جوادی | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Crescent Journal of Medical and Biological Sciences CJMB_58.pdf | 1396/12/07 | 471571 | دانلود |
