چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | توحید قاسم نژاد |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 62359 |
| عنوان فارسی مقاله | DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard |
| عنوان لاتین مقاله | DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Review Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.sciencedirect.com/science/article/pii/S138266891830019X |
| Title: DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard Abstract: Sulfur mustard (SM) is an alkylating agent that causes severe damages to the skin, eyes, and the respiratory system. DNA alkylation is one of the most critical lesions that could lead to monoadducts and cross-links, as well as DNA strand breaks. In response to these adducts, cells initiate a series of reactions to recruit specific DNA repair pathways. The main DNA repair pathways in human cells, which could be involved in the DNA SMinduced DNA damages, are base excision repair (BER), nucleotide excision repair (NER), homologous recombination (HR) and non-homologous end joining (NHEJ). There is, thus, a need for a short review to clarify which damage caused by SM is repaired by which repair pathway. Increasing our knowledge about different DNA repair mechanisms following SM exposure would lay the first step for developing new therapeutic agents to treat people exposed to SM. In this review, we describe the major DNA repair pathways, according to the DNA adducts that can be caused by SM. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر فتاحی | دوم |
| توحید قاسم نژاد | هفتم |
| حمیدرضا نجابتی | سوم |
| سینا آبرون | چهاردهم |
| زینب لطیفی | پنجم |
| ابوالفضل اکبرزاده | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S138266891830019X-main.pdf | 1396/11/27 | 726364 | دانلود |
