| Background: Recently, the clinical importance of dietary inflammatory index (DII) in predicting the inflammatory
potential of diet and its role in pathogenesis of several chronic disease including some types of cancers, osteoporosis,
cardiovascular disease and renal disease has been proposed. However, its association with the disease severity and
progression and cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG)
has not been evaluated yet. In the current study, the association of DII with cardiovascular risk factors among patients
candidate for CABG has been investigated.
Methods: In the current cross-sectional study, 454 patients aged 35-80 years as candidates of CABG and hospitalized in
Tehran Heart Center were enrolled. Anthropometric and demographic characteristics were obtained from all of the
participants. Dietary intakes were evaluated with a semi-quantitative food-frequency questionnaire (FFQ) and DII was
calculated. Biochemical parameters including hemoglobin (Hb) A1C, serum lipids, albumin, creatinine and high-sensitive
C-reactive protein (hs-CRP), lipoprotein (a), creatinine, blood urea nitrogen (BUN), albumin and hematocrit (HCT) were
also assessed by commercial laboratory methods. Left ventricular ejection- fraction, number of diseased vessels, New
York Heart Association (NYHA) functional class and the European system for cardiac operative risk evaluation (EuroSCORE)
were estimated for clinical assessment. One way analysis of variance and chi square tests were used for comparison of
demographic parameters between groups. Beta estimates and 95% confidence intervals (CI) for the association between
DII and clinical parameters were estimated using linear regression adjusted for the confounders.
Results: According to our findings, high DII scores were associated with higher age, lower body mass index (BMI), higher
prevalence of diabetes and myocardial infarction (MI) and lower educational attainment (P< 0.05). Male patients in 4th
and 3rd quartile of DII had significantly higher total cholesterol (TC), triglyceride (TG), albumin, creatinine, BUN and hs-CRP
concentrations and lower high density lipoprotein cholesterol (HDL) concentrations compared with male patients in
lower quartiles (P < 0.05). While in female patients, only lipoprotein (a) concentrations and hematocrit (HCT) percentage
in the 4th and 2nd quartile were significantly higher than lower quartiles. EuroSCORE was also significantly higher in
top quartiles of DII (P = 0.006). |