چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمدرضا علیپور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 62298 |
| عنوان فارسی مقاله | Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats |
| عنوان لاتین مقاله | Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح دو – Medline |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.degruyter.com/view/j/enr |
| Objective. Trans-chalcone is a chalcone with hepatoprotective and anti-infl ammatory eff ects. However, the mechanism of these positive eff ects, especially on miR-451 as an infl ammatory regulator, is poorly understood. In this regard, this microRNA (miRNA) acts by inhibition of hepatic interleukin-8 (IL-8) production in the liver which is one of the main proinfl ammatory cytokines. Th is study for the fi rst time examined the eff ect of trans-chalcone on miR-451/IL-8 pathway. Methods. In present study, 21 male rats were randomly divided into 3 groups (n=7 per each group): control which received solvent (NS), groups 2 (N2T) and 3 (N6T), which received transchalcone for 2 and 6 weeks, respectively. Hepatic level of miR-451 was measured by qRT-PCR. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as hepatic level of IL-8 protein were measured. Results. Trans-chalcone decreased hepatic level of IL-8 protein and serum level of ALT aft er 2 weeks of treatment without signifi cant change in hepatic miR-451. Moreover, it increased hepatic level of miR-451 and reduced hepatic IL-8 as well as AST and ALT aft er 6 weeks. Conclusion. Based on the results of present study, miR-451/IL-8 pathway is a possible mechanism for hepatoprotective action of trans-chalcone in long-term. |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کریمی ثالث | اول |
| محمدرضا علیپور | پنجم |
| ارشد غفاری نسب | سوم |
| مینا سلیمی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ER_2018_52_01-Sales_1-5 (1).pdf | 1396/11/17 | 136030 | دانلود |
| 91014183.pdf | 1396/12/06 | 125778 | دانلود |
