چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | ثریا خیروری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده تغذیه |
| کد مقاله | 62260 |
| عنوان فارسی مقاله | Zinc against advanced glycation end products. |
| عنوان لاتین مقاله | Zinc against advanced glycation end products. |
| ناشر | 3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Systematic Review Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.ncbi.nlm.nih.gov/pubmed/29220086 |
| Advanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age-related chronic diseases. Zinc has antioxidant, anti-inflammatory and anti-apoptotic potential. This study aimed to summarize effects of zinc on AGE formation and AGE-induced damaging agents. Pubmed, Google scholar, Web of Sciences, and Scopus databases were searched. There was no limitation for publication date. English language original articles (in vitro, experimental and human studies) which examined the effect of external zinc on AGE formation, AGE-induced apoptosis, or oxidative stress in mammals were included. To review the effect of zinc on AGE generation, the search keywords were as follows: "zinc" in title and "AGEs" or "methylglyoxal" or "pentosidine" or "carboxymethyllysine" or "glucosylation" or "carbonyl stress" or "AGEs-induced apoptosis or oxidative stress or inflammation" in title/abstract. In total, 90 titles and abstracts were identified. Fifty-two studies were screened after duplicates were removed. Six articles were chosen for review following analysis of both titles and summaries. Finally, based on intensive critical appraisal, 5 articles were included in the study. The evidence presented indicates that zinc has anti-glycation, anti-oxidative and anti-apoptotic effects. Zinc insufficiency may stimulate AGEs formation. Whereas, zinc supplementation could inhibit formation of AGEs, AGE-induced cell apoptosis and oxidative stress status, and protein carbonyl formation possibly through various signalling pathways. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثریا خیروری | اول |
| محمد علی زاده | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Zinc-systematic review.htm | 1396/11/09 | 9678 | دانلود |
| Zinc.pptx | 1396/11/26 | 340231 | دانلود |
