چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | حامد حاجی پور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 62235 |
| عنوان فارسی مقاله | Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers |
| عنوان لاتین مقاله | Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.tandfonline.com/eprint/7EuSwxKkIGCfwKvSVKwF/full |
| The global burden of cancer have encouraged oncologists to develop novel strategies for treatment. Present study was proposed to develop Arginyl-glycyl-aspartic acid (RGD) containing Nanostructured lipid carriers (NLC) as a delivery system for improving the anticancer capability of epigallocatechin gallate (EGCG) on breast cancer cell line by attaching to integrin superfamily on cancer cells. For this purpose, RGD containing EGCG-loaded NLC were prepared by hot homogenization technique and characterized by different techniques. Then cytotoxic and apoptotic effects of prepared nanoparticles and their uptake into cells was evaluated. As results, the nanoparticles with particle size of 85 nm, zeta potential of -21 mV, Encapsulation of 83% were prepared. Cytotoxicity and apoptosis experiments demonstrated that EGCG-loaded NLC-RGD possessed greatest apoptotic activity. Furthermore it has been shown that, EGCG-loaded NLC-RGD causes cell cycle arresting more effective than EGCG. Therefore loading EGCG into NLC-RGD make it more effective in both targeting and accumulation into tumor cells, which results from specialized uptake mechanism by adhesion to αvβ3 integrin. The results strengthen our hope that loading EGCG into RGD containing NLC could possibly overcome the therapeutic limitations of EGCG and make it more effective in cancer therapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد حاجی پور | اول |
| حامد همیشه کار | دوم |
| سعید نظری سلطان احمد | سوم |
| سیامک برقی | چهارم |
| نازیلا فتحی معروفی | پنجم |
| رمضانعلی طاهری | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| full paper.pdf | 1396/11/05 | 2228851 | دانلود |
