چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عباس ابراهیمی کلان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 62134 |
| عنوان فارسی مقاله | کاربرد نانوساینس در تغییر مسیر پیام رسانی mechanistic/mammalian target of rapamycin در سرطانها |
| عنوان لاتین مقاله | Application of nano-sciences in modification of mechanistic/mammalian target of rapamycin signaling pathway in cancers |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | Global Meet on Nanomedicine & Healthcare |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | USA |
| شهر محل برگزاری کنگره/ همایش | New Orleans |
| سال انتشار/ ارائه شمسی | 1396 |
| سال انتشار/ارائه میلادی | 2017 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1396/08/15 الی 1396/08/16 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.alliedacademies.org/proceedings/application-of-nanosciences-in-modification-of-mechanisticmammalian-target-of-rapamyc |
| آدرس علمی (Affiliation) نویسنده متقاضی | Assistant Professor, Department of Neurosciences, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Assistant Professor, Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| فروغ عالمی سرج | اول |
| احمد مهدی پور | سوم |
| زینب علیاری سرج | چهارم |
| محمد پورحسن مقدم | پنجم |
| عباس ابراهیمی کلان | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Nanosciences covers a vast majority of devices derived from biology, engineering and basic sciences which contain nanovectors for the drug delivery system in anticancer drugs. There have been available nanoparticles with various characteristics for optimal drug delivery e.g. for increasing their stability in the circulation system and targeted delivery to the tumors by taking the advantage of enhanced permeability and retention effect near the tumor tissue. Evaluation of the mechanisms and therapeutic effects of nanoparticle-based Mammalian mechanistic target of rapamycine (mTOR) modulation can be useful in developing safe in treatment of cancer. mTOR is a conserved serine/threonine kinase in the cellular PI3K/Akt/mTOR signaling pathway. This pathway is modified by cellular alterations such as level of energy, growth factors, stresses, as well as the increased environmental level of cancerous cytokines. In general, increase of this kinase protein function is seen in various types of cancers, especially in cancer stem-like cell. Additionally, activation of this pathway in the most common cancers like nervous system is in consideration. Recent studies have shown the relationship between different cellular signaling pathways and genetic mutations, that involved in the cancers, with mTOR pathway. Based on previous studies, different treatments like surgery, chemotherapy, radiotherapy, aren’t more effective and have some side-effects. Therefore, the researchers are trying to find better ways to treat cancer. One approach to this aim is about the essence of understanding all of molecular pathways, proteins and mutations involved in cancers. To reach a good efficacy, high distribution and accepted dispersing of utilized drugs in control of mTOR signaling pathway, nanomedicine has been defined as a dramatic manner. In clinic to establish a new mTOR deregulation in human diseases, hereby, we address the recent progress in the field of nanoparticle-based mTOR targeted therapy. |
| کلمات کلیدی | nano-sciences , mechanistic/mammalian target of rapamycin , cancers , signaling pathway |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Application of Nano-sciences ...pdf | 1396/10/24 | 279194 | دانلود |
| acc letter.pdf | 1396/10/28 | 200690 | دانلود |
