Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus: A clinical study.

Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus: A clinical study.


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نویسندگان: فاطمه عباسعلیزاده , پرویز صالح , رعنا دوستی , رضا پیری , محمد نقوی بهزاد , شمسی عباسعلیزاده

کلمات کلیدی: Keywords: Atorvastatin, gestational diabetes, nephropathy, proteinuria

نشریه: 25458 , 2 , 58 , 2017

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نویسنده ثبت کننده مقاله محمد نقوی بهزاد
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه کمیته تحقیقات دانشجویی
کد مقاله 62122
عنوان فارسی مقاله Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus: A clinical study.
عنوان لاتین مقاله Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus: A clinical study.
ناشر 6
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح دو – PubMed
آدرس لینک مقاله/ همایش در شبکه اینترنت http://www.nigeriamedj.com/article.asp?issn=0300-1652;year=2017;volume=58;issue=2;spage=63;epage=67;aulast=Abbasalizadeh

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Background: Gestational diabetes is known as one of the diseases through pregnancy. In the present study, changes in proteinuria after atorvastatin administration among patients with history of gestational diabetes were studied. Materials and Methods: In this randomized clinical trial, 42 patients were included in the study. Atorvastatin was administered for 21 patients, and 21 patients were designated as control group. Lipid profile, protein, and 24 h urine creatinine (uCr) levels were determined in the beginning and 3 months after intervention. P < 0.05 was considered statistically significant. Results: Lipid profile in intervention group was enhanced; low-density lipoprotein (LDL) had decreased while triglyceride had not changed and high-density lipoprotein had been increased. There was no statistically significant change in serum Cr, serum urea, estimated glomerular filtration rate, uCr, urine volume, 24-h urine protein level, or urine protein/Cr ratio on both groups during the study; also, there was no statistically significant difference between groups. Conclusions: Although LDL level decreased after atorvastatin therapy, atorvastatin therapy had no effect on the level of proteinuria or other parameters related to kidney function.

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نویسنده نفر چندم مقاله
فاطمه عباسعلیزادهاول
پرویز صالحدوم
رعنا دوستیسوم
رضا پیریچهارم
محمد نقوی بهزادپنجم
شمسی عباسعلیزادهششم

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