چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمدرضا علی وند |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 62070 |
| عنوان فارسی مقاله | The diversity in the expression profile of caveolin II transcripts, considering its new transcript in breast cancer |
| عنوان لاتین مقاله | The diversity in the expression profile of caveolin II transcripts, considering its new transcript in breast cancer |
| ناشر | 8 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://onlinelibrary.wiley.com/doi/10.1002/jcb.26378/full |
| Most studies have revealed the effects of caveolins in cancer inhibition. However, dueto a lack of reports about their new transcripts, their presence and their effects ondifferent cancers are unclear. This study was conducted to evaluate the cavolin-2(cav-2) transcripts expression changes in tumoral and corresponding tissues and incontralateral breast, to investigate their variation associated with the variation ofcaveolin-1 (cav-1) expression in breast cancer. There were 40 breast-derived tumoral,corresponding, and contralateral tissues obtained from the patients with breast cancer.The RNA and proteins were extracted from these samples. So, cav-1 and cav-2transcripts’ variation were assessed in whole tumoral, corresponding, andcontralateral breast. Also, their expression modifications were evaluated via theWestern blotting technique. The results derived from this study verified the presenceof transcript III of cav-2 for the first time, which was reported only in the gene bank,but we could not detect and validate any protein associated with these transcripts.Also, the decreasing trend of cav-1 and the cav-2 (transcripts I and II) were observedin tumoral tissues compared to unaffected tissues especially in stages I and II. It seemsthat the descending expression levels of cav-1 and cav-2 (transcript I, II) besides thelasting expression of cav-2 (transcript III) are associated with the incidence andpromotion of breast cancer, especially in the initial stages of breast cancer. So, thismay show a potential in determining the patients who can undergo the prophylacticmastectomy. Moreover, the results of the study demonstrated that transcript III maybe a candidate as a non-coding RNA. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمدرضا علی وند | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| JCB-26378_review (proof of majid).pdf | 1396/10/13 | 3105488 | دانلود |
