| Abstract- It is very important to have proper management in children with Seizure. Electroencephalography
(EEG) as a diagnostic instrument has a key role in determining the management method of seizure in
children. Because of poor cooperation of some children (especially children with attention deficit
hyperactivity disorders and developmental disorders) in performing EEG, it is the best choice to sedate
children before EEG. The aim of present study is to evaluate the sedation efficacy of clonidine in children
before EEG. In a randomized clinical trial, 45 children age 2 to 12 with seizure, who referred to Children
Hospital of Tabriz University of Medical Sciences and candidate for EEG, were studied. Sedation before
EEG induced by 0.5 to 2.0 mg clonidine orally. Sedation score (0 to 5) measured by using eyes condition,
response to voice, and response to touch. Successful sedation, EEG performing, and hemodynamic stability
were evaluated during sedation. Of all patients, 40 patients (88.88%) were sedated successfully, and EEG was
performed for all of the children. Mean onset time of clonidine effect was 35.47±13.56 minutes and mean
time of that the patients’ level of consciousness back to the level before administrating of clonidine was
77.55±26.87 minutes. Hemodynamic states of all patients were stable during the study, and there were no
significant changes in vital sign of patients. In conclusion, clonidine can be considered as a safe alternative
medication for sedation for EEG, which is fortunately associated with no significant change in vital signs,
which may complicate overall status of patients.
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