چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عباس دل آذر |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 61894 |
| عنوان فارسی مقاله | ارزیابی فعالیت های بیولوژیک مختلف قسمتهای هوایی اسکروفولاریا فریجیدا ایران |
| عنوان لاتین مقاله | Evaluation of Various Biological Activities of the Aerial Parts of Scrophularia frigida Growing in Iran. |
| ناشر | 8 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.ncbi.nlm.nih.gov/pubmed/28496481 |
| The current study was assigned to evaluate the total phenol, total flavonoid content (TPC, TFC) and antioxidant properties of extracts from the aerial parts of Scrophularia frigida (S. frigida). Extracts were also tested by preliminary phytochemical screening as well as cytotoxic activity against Artemia salina, MCF-7 (human breast carcinoma) and SW-480 (colon carcinoma) and L-929 (normal) cell lines along with antimicrobial characteristic. DPPH, MTT and Brine shrimp lethality tests and disc diffusion method were carried out to determine the biological activities of the different extracts of S. frigida. In addition, the extracts which had more potent antioxidant and antiproliferative activity were further analyzed by NMR and GC-MS. 40% methanol-water (from MeOH extract) fraction showed higher amounts of TPC, TFC and antioxidant property. Findings of the study for general toxicity effect showed that dichloromethane (DCM) and MeOH extracts had weak to moderate effects. Furthermore, DCM extract indicated the most potent anti-proliferative activity against cancer cell lines. No evidence of antibacterial activity was determined. On the other hand, analysis of the potent extract DCM in cytotoxic assay showed the presence of trans-phytol and cis-oleic acid in GCMS. Furthermore, NMR analysis of potent methanolic fractions in antioxidant tests revealed the presence of iridoids and phenolics. Generally, the results of TPC, TFC and antioxidant activity of extracts and fractions were in agreement with each other. |
| نویسنده | نفر چندم مقاله |
|---|---|
| پرینا اصغریان | اول |
| فریبا حشمتی افشار | دوم |
| سولماز اثناعشری | سوم |
| فرزانه لطفی پور بناب | چهارم |
| بهزاد برادران | پنجم |
| عباس دل آذر | هشتم |
| المیرا زلالی | ششم |
| صدیقه بامدادمقدم | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 123.pdf | 1396/09/13 | 343041 | دانلود |
