| Background: The current study was assigned to evaluate the antioxidant,
general toxicity, anti-proliferative and antimicrobial activities of different
extracts obtained from rhizomes of Eremostachys macrophylla (Lamiaceae).
Methods: All activities were evaluated by obtaining extracts of E. macrophylla
in n-hexane, DCM (dichloromethane) and MeOH (methanol) by soxhlet
apparatus. The antioxidant activity of the extracts was evaluated in terms of
FRST (free radical scavenging activity test) by DPPH (2, 2-diphenyl-1picrylhydrazyl).
BSLT (Brine shrimp lethality tests), MTT (3-[4, 5dimethylthiazol-2-yl]-2,
5-diphenyltetrazolium bromide) assay and disc
diffusion method were carried out to determine the general toxicity, antiproliferative
and
antibacterial
activities
of
the
different
extracts,
respectively.
Results:
The findings of the study for antioxidant, anti-proliferative and
antibacterial effects showed that DCM extract was the most active fraction, but
n-hexane extract indicated the most potent effect against Artemia salina.
Conclusion: The results revealed strong bioactive effects of nonpolar fractions
of E. macrophylla rhizomes. Thus, it is possible to suggest some new potential
antioxidant, cytotoxic and antibacterial agents with no harmful effects on
noncancerous cells. |