چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | اسماعیل قره پاپاق |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 61753 |
| عنوان فارسی مقاله | Determination of effect of aspirin and captopril on cat glomerular filtration rate using renovascular hypertension scintigraphy |
| عنوان لاتین مقاله | Determination of effect of aspirin and captopril on cat glomerular filtration rate using renovascular hypertension scintigraphy |
| ناشر | 3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | Tropical Journal of Pharmaceutical Research |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.tjpr.org |
| Original Research Article Determination of effect of aspirin and captopril on cat glomerular filtration rate using renovascular hypertension scintigraphy Esmaeil Gharepapagh1 , Gholamreza Assadnassab2 * and Solmaz Rahmani Barouji 1Department of Radiology, Division of Nuclear Medicine, Tabriz University of Medical Sciences, 2Department of Clinical Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran, 3 School of Traditional Medicine, Tabriz University of Medical Science, Tabriz, Iran *For correspondence: Email: assadnassabgh@iaut.ac.ir; Tel: 989144121145 Received: 11 May 2016 Revised accepted: 12 October 2016 Abstract Purpose: To compare the effects of aspirin and captopril on glomerular filtration rate (GFR) during renal perfusion scintigraphy in cats after experimentally-induced unilateral renal-artery stenosis. Methods: Twenty mixed-breed adult cats weighing 3-4 kg were used. After conducting renal scintigraphy operations, their GFRs were measured by the method of Gate. Four days later, renovascular hypertension was induced through renal-artery stenosis by clipping half of the left renalarteries. Renal scintigraphy was conducted after four days. After confirming the presence of hypertension, the cats were divided into two groups of 10 animals each (aspirin and captopril groups, respectively). The drugs were administered orally to the groups. One hour later, scintigraphic operations were repeated under anaesthesia after injecting 2 mCi of the radiopharmaceutical, technetium-99m diethylene triamine pentaacetic acid (99mTc-DTPA), via the femoral vein as a bolus dose. In all groups, regions of interest (ROIs) were drawn and GFRs were measured by Gate method. Results: Mean total GFR (both right and left kidneys) in operated animals treated with captopril was 5.459 ml/min while the mean value for the left kidney and right kidneys were 1.585 and 3.874 ml/min, respectively. In operated animals treated with aspirin, mean total GFR was 5.440 ml/min, while the values for the left kidney and right kidneys were 1.567 and 3.866 ml/min, respectively. Conclusion: These results indicate that aspirin has similar reduction effect on GFRs and similar shape of renograms as captopril in cat renovascular hypertension scintigraphy. Thus, aspirin is a suitable substitute for captopril in the diagnosis of renovascular hypertension in renal scintigraphy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| اسماعیل قره پاپاق | اول |
| غلامرضا اسدنسب | دوم |
| سولماز رحمانی باروجی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2016_15_11_15.pdf | 1396/09/26 | 360255 | دانلود |
