چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | میترا جلوه گری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 61747 |
| عنوان فارسی مقاله | Fast Dissolving Oral Thin Film Drug Delivery Systems Consist of Ergotamine Tartrate and Caffeine Anhydrous |
| عنوان لاتین مقاله | Fast Dissolving Oral Thin Film Drug Delivery Systems Consist of Ergotamine Tartrate and Caffeine Anhydrous |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_823_20150213185122 |
| Abstract
Ergotamine tartrate (ET), a serotonin 5-HT1 receptor agonist, is an anti-migraine drug. Due to high first-pass metabolism, ET shows a very low bioavailability in oral administrations (<1%). Caffeine (CA) increases the rate and extent of water solubility of ET. The present study intended to investigate the possibility of developing ET fast dissolving thin films for the fast drug dissolution in the oral cavity, and thus bypassing first pass metabolism for providing quick onset of action of the drug. Methods: The films (ET and CA) were prepared according to solvent casting method, separately. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E-15) was employed in preparation as a film forming polymer. Propylene glycol was the plasticizer used. All the films were evaluated for their thickness, weight variations, folding endurance, surface pH, disintegration, drug content, DSC, in-vitro drug release, and ex-vivo permeation. Results: The best polymer drug ratio in ET/CA films was 1:20 (E2) and 1:4 (C2), respectively. The films E2 and C2 showed 9.9, 3.2 mg weight, 74, 45 µm thickness, 120.66, up to 300 folding endurance and 0.38, 0.52 mg/cm2 drug content, respectively. The DSC showed no stable characteristic for ET and CA in the drug loaded films and revealed amorphous form. The results showed that ET films prepared had faster release and CA films had slower release (p |
| نویسنده | نفر چندم مقاله |
|---|---|
| میترا جلوه گری | اول |
| سعیده سلطانی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| PHARM-21-102.pdf | 1396/08/16 | 805260 | دانلود |
