چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | نصرت اله ضرغامی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 61740 |
| عنوان فارسی مقاله | Serum Levels of Vaspin and Its Correlation with Nitric Oxide in Type 2 Diabetic Patients with Nephropathy |
| عنوان لاتین مقاله | Serum Levels of Vaspin and Its Correlation with Nitric Oxide in Type 2 Diabetic Patients with Nephropathy |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.eurekaselect.com/152780/article |
| Abstract BACKGROUND: Diabetic nephropathy (DN), a serious and prevalent complication of diabetes, has been rapidly raising worldwide. Vaspin, as an adipokine with anti-diabetic effects, is predominantly released from visceral adipose tissue. Moreover, vaspin has the stimulatory effect on nitric oxide (NO) bioavailability through the activation of NO synthase. OBJECTIVE: The aim of the present study was to investigate serum levels of vaspin and their correlation with NO metabolite in diabetic patients with normal renal function and renal insufficiency. METHODS: Volunteers patients with non-nephropathy type 2 diabetic mellitus (T2DM) as control (n=40, age= 56.95±6.11years) and patients with diabetic nephropathy (DN) (n=40, age=57.85±5.63years) as case group were enrolled in this study, and serum samples were collected for measurement of vaspin levels by ELISA technique. Also, serum levels of NO metabolites were calorimetrically assessed. RESULTS: We found that vaspin levels were significantly decreased in diabetic patients with nephropathic condition as compared with diabetic patients with normal renal function (p <0.04). In addition, serum levels of NO metabolites were significantly higher in diabetic patients with nephropathy in comparison with non-nephropathic diabetics (p<0.001). When patients with DN were studied, vaspin levels were positively correlated with NO metabolites and Homeostasis model assessment of insulin resistance (HOMA-IR) levels. CONCLUSIONS: This study showed that low serum vaspin levels may be a risk factor for nephropathy in type II diabetic patients and increased levels of NO may be a defensive mechanism in DN. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نصرت اله ضرغامی | ششم |
| محمد رحمتی | دوم |
| علی مطاع | سوم |
| سیما عابدی آذر | چهارم |
| یونس پیله ور سلطان احمدی | ششم |
| آیناز میهن فر | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Serum Levels of Vaspin and Its Correlation with Nitric Oxide in Type 2 Diabetic Patients with Nephropathy _ BenthamScience.pdf | 1397/09/20 | 197761 | دانلود |
