چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سیاوش دستمالچی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات بیوتکنولوژی(زیست فناوری) |
| کد مقاله | 61724 |
| عنوان فارسی مقاله | Determination of Pyridine as a Decomposition Product in Ceftazidime and Mouthwash Solution |
| عنوان لاتین مقاله | Determination of Pyridine as a Decomposition Product in Ceftazidime and Mouthwash Solution |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Short Communication |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://link.springer.com/article/10.1007/s10337-017-3241-2 |
| Abstract: In this study, a dynamic headspace liquid-phase microextraction method is reported for the extraction and preconcentration of pyridine as a decomposition product in some pharmaceuticals before its determination by gas chromatography–flame ionization detection. In the practical procedure, 5 µL of dimethyl sulfoxide (extraction/collection solvent) containing 1-pentanol (internal standard) is placed into a liner-shaped extraction vessel. The vessel is passed through the septum of a vial containing the sample solution. Then it is placed into a water bath thermostated at 70 °C. After a predetermined time, 1 µL of the extraction/collection solvent is removed and injected into the separation system. The factors influencing the extraction efficiency including extraction/collection solvent kind and its volume, ionic strength, extraction time, extraction temperature, and pH were investigated and optimized. Under optimum extraction conditions, the method showed a wide linear range between 0.012 and 500 mg L−1. Enrichment factor and extraction recovery were obtained as 314 and 94%, respectively. Limit of detection was calculated as 0.004 mg L−1 in solution and 0.08 mg kg−1 in solid. Relative standard deviation for the extraction of 0.05 mg L−1 of the analyte was obtained as 4 and 6% for intra-day (n = 6) and inter–day (n = 4) precisions, respectively. Finally, the target analyte was determined in ceftazidime and mouthwash solution by the proposed method. Graphical Abstract: [Figure not available: see fulltext.] © 2017, Springer-Verlag Berlin Heidelberg. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیاوش دستمالچی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1007%2Fs10337-017-3241-2 (1).pdf | 1396/08/16 | 614988 | دانلود |
