The correlation between inflammatory and metabolic parameters with thyroid function in patients with Hashimoto’s thyroiditis: The potential role of interleukin-23 (IL-23) and vascular endothelial growth factor (VEGF)-1

The correlation between inflammatory and metabolic parameters with thyroid function in patients with Hashimoto’s thyroiditis: The potential role of interleukin-23 (IL-23) and vascular endothelial growth factor (VEGF)-1


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دانشگاه علوم پزشکی تبریز
دانشگاه علوم پزشکی تبریز

نویسندگان: مهدیه عباسعلیزاد فرهنگی , غزاله حاجی لوئیان

کلمات کلیدی: Hashimoto’s thyroiditis, IL-23, TGF-β, VEGF, Nesfatin-1.

نشریه: 326 , 2 , 13 , 2018

اطلاعات کلی مقاله
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نویسنده ثبت کننده مقاله مهدیه عباسعلیزاد فرهنگی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه دانشکده تغذیه
کد مقاله 61585
عنوان فارسی مقاله The correlation between inflammatory and metabolic parameters with thyroid function in patients with Hashimoto’s thyroiditis: The potential role of interleukin-23 (IL-23) and vascular endothelial growth factor (VEGF)-1
عنوان لاتین مقاله The correlation between inflammatory and metabolic parameters with thyroid function in patients with Hashimoto’s thyroiditis: The potential role of interleukin-23 (IL-23) and vascular endothelial growth factor (VEGF)-1
ناشر 2
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت http://www.acta-endo.ro/Archive/Abstract?doi=2017.X11

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Context. Hashimoto’s thyroiditis is an autoimmune disorder as the most common cause of hypothyroidism. It has been proposed that the disease is associated with numerous inflammatory and metabolic disturbances. Objectives. The current study was aimed to evaluate several inflammatory and metabolic predictors of Hashimoto’s thyroiditis. Design. Descriptive, Cross-sectional study. Subjects and Methods. Forty patients with Hashimoto’s thyroiditis, aged between 22-50 years old, participated in the current study. Anthropometric and nutritional measurements were assessed and biochemical factors including serum VEGF, IL-23, Nesfatin-1 and serum lipids were measured. Results. Waist circumference was higher among patients with lower serum TSH concentrations. Serum HDL and T4 concentrations were lower and serum IL-23 was higher among patients with higher TSH concentrations. BMI, WC and serum HDL were negative predictors of serum TSH while IL-23 was positively associated with TSH concentrations. Serum lipids including TC, TG and LDL were also negatively associated with T3 and T4 concentrations. Conclusions. According to our findings, VEGF and serum IL-23 were potent predictors of Hashimoto’s thyroiditis. However, further studies are warranted to better clarify these associations and underlying pathogenic mechanisms.

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نویسنده نفر چندم مقاله
مهدیه عباسعلیزاد فرهنگیاول
غزاله حاجی لوئیاندوم

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