| Context. Hashimoto’s thyroiditis is an autoimmune
disorder as the most common cause of hypothyroidism. It has
been proposed that the disease is associated with numerous
inflammatory and metabolic disturbances.
Objectives. The current study was aimed to
evaluate several inflammatory and metabolic predictors of
Hashimoto’s thyroiditis.
Design. Descriptive, Cross-sectional study.
Subjects and Methods. Forty patients with
Hashimoto’s thyroiditis, aged between 22-50 years old,
participated in the current study. Anthropometric and
nutritional measurements were assessed and biochemical
factors including serum VEGF, IL-23, Nesfatin-1 and serum
lipids were measured.
Results. Waist circumference was higher among
patients with lower serum TSH concentrations. Serum HDL
and T4 concentrations were lower and serum IL-23 was
higher among patients with higher TSH concentrations.
BMI, WC and serum HDL were negative predictors of
serum TSH while IL-23 was positively associated with TSH
concentrations. Serum lipids including TC, TG and LDL were
also negatively associated with T3 and T4 concentrations.
Conclusions. According to our findings, VEGF
and serum IL-23 were potent predictors of Hashimoto’s
thyroiditis. However, further studies are warranted to
better clarify these associations and underlying pathogenic
mechanisms. |