چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | حامد همیشه کار |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 61559 |
| عنوان فارسی مقاله | Preparation and Characterization of Rutin-loaded Nanophytosomes |
| عنوان لاتین مقاله | Preparation and Characterization of Rutin-loaded Nanophytosomes |
| ناشر | 3 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح سه – Scopus |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://journals.tbzmed.ac.ir/PHARM/Manuscript/PHARM-21-145.pdf |
| Background: Plant-derived materials are increasingly gaining attention as dietary supplements and due to their role in medicinal application. Rutin, a phenolicantioxidant, is a member of bioflavonoids which has been demonstrated to scavenge superoxide radicals and is believed to be a vital nourishing supplement due to its ability to strengthen and modulation of the permeability of the blood vessels walls. However, Rutin shows poor absorption when administered orally and its bioavailability is an important restrictive factor. Purpose: The present study was aimed to prepare and characterize a stable Rutin-loaded nanophytosomal formulation to improve its antioxidant property and bioavailability. Methods: Rutin-loaded nanophytosomes were prepared by phosphatidylcholine (PC) and cholesterol by thin layer hydration method. The physicochemical properties of prepared nanophytosomes were evaluated using particle size analyses, Furrier transformation infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Stability of the prepared nanophytosomes was also investigated during three weeks of storage period. Results: Results showed that formulation with the Rutin: PC molar ratio of 1:2 possess lowest particle size and the incorporation of cholesterol improved the physical stability of nanophytosome for over three weeks. FTIR and DSC analysis showed the formation of Rutin-phospholipid complex during the formulation development process. Conclusion: Results of the present study showed that nanophytosome can be introduced as a useful carrier for fortifying herbal medicinal compounds for application the formulation of various food and pharmaceutical products. |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد همیشه کار | سوم |
| زهرا حوراسفند | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2015-Hooresfand-PS.pdf | 1396/07/21 | 744939 | دانلود |
