چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | ندا دولت خواه |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | طب فیزیکی وتوانبخشی |
| کد مقاله | 61558 |
| عنوان فارسی مقاله | تأثیر مکمل پروبیوتیک در زنان مبتلا به دیابت بارداری بر بیومارکرهای التهابی و استرس اکسیداتیو: یک کارآزمایی بالینی تصادفی شده |
| عنوان لاتین مقاله | Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomarkers: a randomized clinical trial |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://pdfs.semanticscholar.org/c2b2/6a62cc4dbe1bdbc7e16542a549646c207b50.pdf |
| Background and Objectives: Very little is known about the use of probiotics among pregnant women with gestational diabetes mellitus (GDM) especially its effect on oxidative stress and inflammatory indices. The aim of present study was to measure the effect of a probiotic supplement capsule on inflammation and oxidative stress biomarkers in women with newly-diagnosed GDM. Methods and Study Design: 64 pregnant women with GDM were enrolled in a double-blind placebo controlled randomized clinical trial in the spring and summer of 2014. They were randomly assigned to receive either a probiotic containing four bacterial strains of Lactobacillus acidophilus LA-5, Bifidobacterium BB-12, Streptococcus Thermophilus STY-31 and Lactobacillus delbrueckii bulgaricus LBY-27 or placebo capsule for 8 consecutive weeks. Blood samples were taken pre- and post-treatment and serum indices of inflammation and oxidative stress were assayed. The measured mean response scales were then analyzed using mixed effects model. All statistical analysis was performed using Statistical Package for Social Sciences (SPSS) software (version 16). Results: Serum highsensitivity C-reactive protein and tumor necrosis factor-α levels improved in the probiotic group to a statistically significant level over the placebo group. Serum interleukin-6 levels decreased in both groups after intervention; however, neither within group nor between group differences interleukin-6 serum levels was statistically significant. Malondialdehyde, glutathione reductase and erythrocyte glutathione peroxidase levels improved significantly with the use of probiotics when compared with the placebo. Conclusions: The probiotic supplement containing L.acidophilus LA- 5, Bifidobacterium BB-12, S.thermophilus STY-31 and L.delbrueckii bulgaricus LBY-2 appears to improve several inflammation and oxidative stress biomarkers in women with GDM. |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه جهانجو | دوم |
| فاطمه عباسعلیزاده | سوم |
| ناصر آقا محمد زاده | چهارم |
| مهران مسگری عباسی | پنجم |
| ندا دولت خواه | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2018-188_Compressed.pdf | 1397/09/11 | 2391851 | دانلود |
