چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | حامد خدائی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 61481 |
| عنوان فارسی مقاله | Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin |
| عنوان لاتین مقاله | Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin |
| ناشر | 4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://onlinelibrary.wiley.com/wol1/doi/10.1002/jsfa.8261/full |
| BACKGROUND: 5-Hydroxymethylfurfural (5-HMF) is one of the most important products of theMaillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti-allergic effect of 5-HMF by investigating some selected components of the immune response in BALB/c mice immunisedwith ovalbumin (OVA). RESULTS: Immunised animals had an increased level of serum total and OVA-specific antibodies when compared to the control (P < 0.01).We found that the OVA-induced increase in serum IgE and OVA-specific IgE were significantly suppressed in the groups treatedwith 5-HMF (P <0.05). Moreover, interleukin-4 (IL-4) and interferon gamma (IFN-𝜸)were significantly reduced in a dose-independent manner when compared to the sensitised group (P < 0.05). CONCLUSION: 5-HMF inhibited the up-regulation of total andOVA-specific IgE through the suppression of the Th2-type immune response in immunised BALB/c mice. 5-HMF could therefore be a novel therapeutic approach for the prevention of IgE-mediated allergic diseases. |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد خدائی | دوم |
| محمد علی زاده | اول |
| مهران مسگری عباسی | سوم |
| سودا صالح قدیمی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 13993407.pdf | 1396/07/06 | 466859 | دانلود |
| Presentation1.jpg | 1396/07/12 | 186176 | دانلود |
| Presentation2.jpg | 1396/07/12 | 125700 | دانلود |
